Sequence-dependent DNA helical rise and nucleosome stability

Preferential Nucleosome Occupancy at High Values of DNA Helical Rise

Nucleosomes are the basic structural units of eukaryotic chromatin and play a key role in the regulation of gene expression. Nucleosome formation depends on several factors, including properties of the sequence itself, but also physical constraints and epigenetic factors such as chromatin-remodelling enzymes. In this view, a sequence-dependent approach is able to capture a general tendency of a...

DNA sequence mediates nucleosome structure and stability.

New and Notable DNA Sequence Mediates Nucleosome Structure and Stability

Nucleosomes form the fundamental repeating unit of eukaryotic chromatin. Subtle modifications in nucleosome structure and histone tails regulate chromatin states; hence, a comprehensive understanding of alterations in nucleosome structure is of fundamental importance in chromatin biophysics. The nature of core histone organization and nucleosome dynamics have been extensively studied using biop...

Role of DNA sequence in nucleosome stability and dynamics.

The mechanics behind DNA sequence-dependent properties of the nucleosome

Chromatin organization and composition impart sophisticated regulatory features critical to eukaryotic genomic function. Although DNA sequence-dependent histone octamer binding is important for nucleosome activity, many aspects of this phenomenon have remained elusive. We studied nucleosome structure and stability with diverse DNA sequences, including Widom 601 derivatives with the highest know...